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Chapter 1515: Add more burdens

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    "The price of sildenafil in North America is US$7. After excluding the cost, we can get a gross profit of about five yuan per pill. This is mainly because Greenstone Point has borne a lot of the initial costs. They want to win the Westland  Nafei's global sales agent is willing to bear a little more" Yang Rui held the report in his hand, but did not open it, but introduced it to Director Hu as if reciting it.  Director Hu is the director of the Chemical Drug Promotion Office, which is regarded as a supervisory unit of Huarui.  Of course, Yang Rui can also report to the Food and Drug Administration and other departments of the Ministry of Health, but that is unnecessary and people will be embarrassed to listen to it.  Director Hu listened very seriously.  What exactly is new medicine? Before Yang Rui, there was really no experience in the country.  Although there are so many drugs approved by the country every year, except for generic drugs, the rest are proprietary Chinese medicines.  The only way to make money from Chinese patent medicines is at home, and the money you make is the most boring money.  In the 1960s and 1970s, the country still exported Chinese patent medicines to Southeast Asia, Hong Kong and Macao, but after the 1980s there were very few.  The main reason can be said to be the influence of many cultural factors, among which the influence of the FDA is inevitable.  Before the FDA, the quality of drugs in Europe and the United States was actually not very good. It was not common to eat dead people, but it was common to eat disabled people. There were not many diseases that could be treated. Many common diseases were incurable, especially terminal diseases such as cancer.  The survival time of taking Western medicine and Chinese medicine is almost the same, and it basically depends on the individual's physical constitution and spirit.  But after the 1980s, the level of Western medicine in common diseases has obviously reached a higher level.  From a scientific research perspective, the biological technologies studied by the generation of scholars who grew up after World War II, especially those who grew up in the era of genetics, have finally begun to be applied in the field of people's livelihood.  For example, although the cancer-conquering plan launched by Dalbecco in the 1970s failed, the US$1 billion was not a complete waste. The research results generated by this money were finally released one after another in the 1980s and 1990s.  .  With such a scientific research foundation, there is room for Western strong politics to flourish.  By around 1990, countries in Southeast Asia had established corresponding drug review mechanisms, and it was difficult to implement traditional Chinese medicine in the past.  For a leader like Hu Chi, he hates and fears words like FDA and Western medicine.  This feeling is a bit like Chinese football facing the five major leagues and the World Cup. On the one hand, he is eager to enter the game. On the other hand, the key to deciding to enter the game is not himself.  In addition to trying his best to understand the situation and issuing some useless orders, all he could do was to promote that football originated from Cuju. During the Song Dynasty, there were Cuju masters who used the ball to enter the Tao and reach Tianting  If it passes the FDA review, it is equivalent to a player entering a wealthy Premier League club. If it sells well, it is equivalent to becoming famous. Hu Chi naturally wants to know the details.  If he wants to know, Yang Rui will introduce him.  He first talked about the review process of clinical phase III and clinical phase IV, and then talked about the later negotiations with Pfizer, and then talked about the contract and sales policy of Greenstone Corner, and then talked about the performance of sildenafil in the market and its withdrawal.  Several modes of funding.  Hu Chi was confused when he heard this.  "The Chinese in the 1990s knew too little about foreign countries. Even pseudo-high-level officials like Hu Chi did not understand the professional situation in the medical field.  After listening for a while, Hu Chi finally gave up and decided to start with the part he knew. He smiled and said: "It seems like you have made money, hahahaha" "You can make money, that's it.  , I want to talk about where the funds are going." Yang Rui also said the goal of his trip.  Hu Chi nodded repeatedly: "Funds have to be spent to be valuable, you say." "Peking University Ion Channel Laboratory is ready to participate in the genome project. The instruments, equipment, personnel and training have been completed. Can you please  Come forward and urge negotiations. "The Human Genome Project is an international cooperation, that is, a plan between countries, so it needs to be negotiated on a national basis.  Of course, Yang Rui had already finished the preliminary communication, and there was not much professional part left. The rest was all political and diplomatic work.  However, political diplomacy is also the most complicated part.  In the context of international cooperation and confrontation, no one knows whether they will become a bargaining chip in exchange.  The international situation in the 1990s was very unfriendly to China. It was a world of difference from the mid-1980s.  When Yang Rui won the Nobel Prize, the media praised him wherever he went. There was even a voice within the Nobel Prize Committee that hoped to give China a Nobel Prize and promote the development of China's democratic cause from the side But in the 1990s,  Years later, the voice of the media has completely changed, and everything in China will become wrong.  Yang Rui was almost always banned when he cloned sheep.It is a threat This is political correctness in the Western world and what various committees care about most.  "If the pharmaceutical companies were really powerful, the pharmaceutical system was really rich, the lobbying groups were really powerful, and the talkers really needed to use it, the passage of sildenafil would have been subject to various restrictions.  Therefore, Yang Rui is not very relaxed about joining the Human Genome Project.  Hu Chi also knew the difficulty of this matter and mused: "You also know the current diplomatic situation. I can only say that I am doing my best." "Well" Yang Rui rubbed his chin and said: "If necessary, we  Peking University can provide some help, such as funds and personnel. "With his current influence, it is enough to represent Peking University.  ¡°As long as projects like the Human Genome Project are won, Peking University¡¯s influence will be greatly enhanced. This is a great thing that both sides are looking forward to.  Hu Chi didn¡¯t expect Yang Rui to say such a thing, and couldn¡¯t help laughing: ¡°As for sildenafil, they should also help.¡± ¡°It¡¯s better to give something real.¡± Yang Rui gave the money generously.  Green Stone Corner has spent tens of millions of dollars on lobbying in the United States, tens of thousands or even hundreds of thousands of dollars, holding seven or eight receptions at a time, which is enough to attract 800 people in China. It has been three and a half years since I returned home in glory.  Units like the Ministry of Foreign Affairs are very happy for their employees. Even if they don¡¯t have any gray income, they can make a lot of money by saving a little travel expenses and buying some foreign specialties. But for the unit itself, the cost of each business trip has to be used  Foreign exchange, I dare not say that it is rich.  ¡°Similarly, there are actually units such as the police station¡¯s criminal police team. Although the employees are nourished on weekdays, when it comes to handling cases, they often drive thousands of miles to collect evidence, and the food and accommodation expenses for long-term stays are not a small amount.  It is because Yang Rui knows this that he often donates money to the police departments within his jurisdiction.  By the same token, he doesn't mind donating money to the foreign affairs department. ?? If you don¡¯t count cheats, if you analyze what is the difference between him and his contemporaries, apart from his good looks, the main reason is that he is rich.  If you analyze it carefully, you are rich and generous.  Even if other domestic scholars receive large sums of funding, most of them will not use it because of their past experiences. This is an era when frugality is still regarded as a virtue.  Yang Rui doesn¡¯t have this habit anymore. Scientific research has reached its peak, which is actually krypton gold.  Any high-level skill, if you want to improve it, you have to spend several times, dozens of times or even hundreds of times the money of the previous level.  In 1990, China was still accustomed to doing follow-up research. To put it simply, it was used to following the big guys, and it was not self-conscious to enter the world on its own. When spending money, it was natural to consider cost-effectiveness.  However, being the number one server is never cost-effective.  Although Hu Chi was not used to such straightforward operations, when he saw Yang Rui's insistence, he agreed and turned around and said, "In this case, you have to consider the issue of domestic competition." This was his intention to mention something to Yang Rui.  .  Yang Rui is no longer the Chu brother he was back then. He smiled and asked, "Have you received any news?" "You know my current position. There will always be people who will come to test me." Hu Chi first explained, and then said:  "Peach pickers are always indispensable." "Do you think they can pick them?" Yang Rui asked slightly seriously.  Throughout the country, Yang Rui is not the only one calling for the Human Genome Project.  Although Yang Rui shouts about the Human Genome Project from time to time, and even shouted at the Nobel Prize scene, when the national team decides the order, it is never judged based on the loudness and frequency of the sound. ?????????????????????????????????????????????????????????????????????????????????????????????????? The Nobel Prize is just an award, not a qualification. Faculty members are.  ¡°Moreover, although the international reputation of Professor Cai, Wu Hongbo, and Academician Zhu cannot be compared with Yang Rui, their domestic reputation is not weak at all.  When the Human Genome Project is established, it is not impossible to give Yang Rui a deputy team leader and then replace the team leader.  Of course, Hu Chi supports Yang Rui, so he specially reminded him, and said: "If you pay more attention, there should be no problem, but you can't help but take it to heart." Speaking of this, Hu Chi said: "You have attended more meetings recently.  Okay, let me give you a reminder. In addition, you can also mention the human genome project and set up a preliminary group. " Yang Rui said a little bored: "How can I have time to do so many useless things.The" "The preparation group is just lining up to eat the fruit. It has to settle the rest of the people, and everyone is happy, but they won't all come to grab it. It is equivalent to promising everyone to be divided into officials, and then keeping one for themselves.  But Yang Rui is not willing to do this. Arranging seats is not as easy as imagined, and it is not his specialty. The most important thing is that the Human Genome Project will really do things.  Son, who will do the work? Hu Chi asked: "What do you have to do recently?  " Yang Rui clapped his fingers and said: "I have to go to class, and Sinovel also has to consider developing new drugs. The Ion Channel Laboratory and Sinovel Laboratory are also doing regular research. In addition, I also plan to make a drug.  valley.  " "Medicine Valley?  " " Concentrating some drug-related enterprises is just like a development zone, but it is done by Huarui Private, which does not pursue short-term benefits, and does not have the trouble of the development zone to take care of this and that. It is simply to concentrate the industry and concentrate it.  In addition, we provide supporting housing to enterprises, which are only for rent but not for sale, so as to reduce their worries.  Yang Rui paused and said, "The loan limit given by Bank of China is almost 10 billion, and it needs to be used out."  " "Is it large in scale?  " "Now it occupies a large area of ??Pudong, and Shenzhen has also given a large area of ??land.  It looks like it can accommodate hundreds of companies, and there is still room left.  Yang Rui paused and said in an understatement: "The construction of the factory is the responsibility of the company itself. However, in order to attract pharmaceutical companies, we have to undertake a large amount of residential construction. It is currently estimated that it must be able to accommodate at least 500,000 workers. Plus the follow-up  Yes, that would be 1 million suites. The amount given by Bank of China is just right.  " Hu Chi's eyes twitched: "Don't we have to repay the loan?  " "There will still be subsequent profits. Besides, isn't there rent?  It would save a lot of trouble if each unit pays it.  " "But 1 million sets?  " "Build it slowly, don't be in a hurry.  The loans provided by the Bank of China are not unconditional. They are also willing for us to invest in infrastructure construction.  If all the money was used to make new medicines and buy machinery and equipment, they would be worried.  " "This is the same, but your plan is really big.  " Yang Rui laughed twice and said: "I originally proposed an idea, but it turned out that the governments of the two places were too active. They sold land at a low price and subsidized it with policies.  " "Then you have to be careful not to be unable to fill the gap when the time comes.  " "The Bank of China's loans are issued in proportion to our U.S. dollars, and the risk is not very high.  "Yang Rui laughed naively, somewhat guilty. How much will the 1 million suites in Shanghai and Shenzhen be worth in 20 or even 30 years? Yang Rui himself is a little afraid to calculate. He can only say, Hua  If Rui wants to develop new drugs in the future, rent will be enough. There are many state-owned enterprises that rely on rent to survive, but for Yang Rui, Medicine Valley is really to solve the current problem.  Question. Bank of China¡¯s loans must be spent, and they cannot be spent in places that are too risky. Otherwise, others will intervene. In this case, infrastructure investment is the best choice.  It is indeed necessary to have concentrated industrial bases in big cities. With the popularity of sildenafil, Sinovel's nationwide sales network has been greatly strengthened, and the brand has gradually become more prominent. At this time, we cannot only look at high-end products.  The development of new drugs. With China¡¯s industrial scale and consumer market, once it is involved in the production of various generic drugs, the industrial park with hundreds of thousands of workers really cannot be ahead of its time. As for 1 million housing units, in this context, more  It's just to increase Yang Rui's personal satisfaction - everyone knows that the house is going to be huge, so there is no reason not to buy two more. For this reason, Yang Rui also asked to build the house as big as possible on the grounds of providing high-standard housing.  Chi couldn't guess Yang Rui's thoughts. As soon as his thoughts changed, he returned to the previous topic and said: "Since you want to make a medicine valley, it's better to do this. In the name of the Chemical Drug Promotion Office, I will use the GMP standards you worked on before.  It was announced in advance.  " "Is it promulgated now?  " "The policies and regulations are all ready. If they are implemented on January 1 next year, the review can begin this year.  You have been pushing this matter all along, and you also need to spend time understanding the status of various pharmaceutical companies, so it¡¯s up to you to catch it.  How about creating another committee from the existing GMP committee?  "Hu Chi took it for granted and expressed full respect for Yang Rui. Yang Rui was surprised and saw the murderous intent. The GMP standard Hu Chi mentioned is a rigid standard for pharmaceutical companies. If it cannot pass, other  The result is a shutdown.As the designer of standards, Yang Rui is well aware of the difficulties of standards. Historically, there were more than 4,000 domestic pharmaceutical companies. In the end, only more than 2,000 were left, including the new ones, which is equivalent to half of the pharmaceutical companies.  , facing the crisis of being annexed or bankrupt.  The committee responsible for standard review and its person in charge hold the power of life and death for all pharmaceutical companies in the country.  In this kind of comprehensive review, even a prestigious company may be eliminated due to shortcomings in some aspects - Yang Rui looked at Hu Chi and was silent for a while. Such a major decision must not be taken.  Patting my head, it suddenly occurred to me.  Hu Chi deliberately pretended to be stupid and laughed twice, and said: "You are in charge of the GMP audit committee. You will have great power immediately. It is convenient to make medicine, and no one dares to pick your peaches, right?"
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