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Chapter 361
Human trials
"No, I can't die!"
Suddenly, Mark suddenly opened the quilt on his body, put on the patient's gown and slippers again, and gently pushed open the door of the ward. //www.//Just like last time, there was no one on the corridor of the special ward. He looked around and saw that the nurses in the nurse station seemed to be busy. If there was no bell ringing, obviously they would not notice him. .
Holding on to the wall of the corridor, Marko staggered towards the fire stairs. A few minutes later, Marco, who was breathing heavily and suffering from a low fever, walked out of the hospital. After stopping a rickshaw, he directly reported "Yaxin Medicine". Although the low fever made his consciousness a little cloudy, he still But he knows that only he can save himself now.
¡°Chemotherapy!¡±
Sitting on the tricycle, Marko's mind kept thinking about a new medical method pioneered by his mentor when he was studying in Germany.
At the turn of the 19th century and the 20th century, it can be said that there are new inventions every moment. This is an era of explosion of inventions, and the same is true for the pharmaceutical industry. In this era, Paul? Ehrlich is the most eye-catching person in the medical science community. It was Ehrlich and his colleagues who conducted long-term experimental research seven years ago. Hundreds of newly synthesized organoarsenic compounds were screened, and the 606th compound was finally determined to have anti-syphilitic activity. This is the first organized and purposeful discovery of optimized biological activity through chemical modification of a lead compound. Tried to treat syphilis and other spirochetes, it is effective and relatively safe. Although the side effects of either 606 or 914 are too great, these drugs have pioneered a precedent - chemotherapy.
Eulich and others have discovered chemical treatments for a number of diseases, such as trypanosomiasis, caused by protozoa, or syphilis, caused by unusual bacteria. For more common and smaller bacteria, purely chemical treatments are ineffective.
Just like the bacteria that Mark is now infected with, they are the bacteria that cannot be treated by the two drugs. However, as early as last year, out of continuing to treat Paul in Germany? For research in Ehrlich's laboratory, Marko began to use the company's funding to continuously try chemical treatments. The wide variety of chemicals in Lianyungang gave him sufficient raw materials to conduct chemical treatment experiments.
For example, Republic Dye Company has launched hundreds of various dyes in the past year. In Marko's experiments, he used almost every known compound, so that his laboratory sometimes needed Hundreds of test mice were sent to the incinerator. Those test mice were either poisoned by the compound or died of various bacterial infections.
Obtaining test data through extensive trials is the only way to develop drugs in this era, and among those trials, some have made certain progress, such as a compound "Orange 36", which is A new type of synthetic dye.
Before Marko was admitted to the hospital, he had injected "Orange 36" into infected mice. The test results were promising. It could kill streptococci. Although before further testing, Marko was hospitalized. He entered the hospital, but at this time, "Orange 36" was his life-saving straw.
Although it is still unclear about the pharmacology of "Orange 36", or even whether it has a therapeutic effect on the bacteria he is infected with, in any case, in Marko's view, this may be his last chance.
¡°Professor Ma, what¡¯s wrong with you?¡±
When Xiang Songmao, who was about to visit Mark Duo in the hospital, saw him outside the gate, he greeted him quickly and hurried over to pay for his tricycle fare. From the hospital gown on his body, he could guess something.
"Manager Xiang, I'm here to save my life!"
After Mark Duo, who was always sociable, left such a sentence, he left Xiang Songmao, who was a little confused. Then he walked straight into the research institute of the big pharmaceutical company.
As soon as you enter the test room, you will be greeted by the familiar smell of compounds, and in the cages in the test room, there are also white mice for testing. Among them, there are more than a dozen white mice whose bodies are slightly red. They are white mice injected with the "orange 36" compound.
In the past few months of experiments, Marko injected a small amount of streptococci into the abdominal cavity of mice. The streptococci reproduced at a rate of 20 minutes. Within a few hours, the abdominal cavity and blood were filled with streptococci. Within 48 hours, the mice All died of sepsis. After thousands of experiments, Marko and his students finally discovered a compound named Orange 36-4 that had no antibacterial effect in the test tube-
Sulfonamide
¨C
2,4
¨CThe hydrochloride of diamine azobenzene, used to treat mice infected with streptococci.It is excellent, but its disadvantage is that it dyes white mice bright red.
A white mouse with a slightly reddish body was caught from the cage. The stain was obviously slowly fading away. This mouse, like other mice, had been injected with diamine azobenzene hydrochloride. They did not die. Sepsis, even the streptococci in the body have been killed.
What does it do?
Marko didn't know this clearly. His hot body and increasingly blurred consciousness reminded Marko that he didn't have much time. According to the fatal mechanism of bacteria, he still had at most one day, which meant that he had no time at all. For further research, you can only test it on yourself.
"Try it!"
Picking up the test report on the table and looking through it, he found that even though he was admitted to the hospital, his students still conducted the test seriously. They studied the toxicity of Orange 36 and the tolerance of mice and rabbits. The dosage is 500mg
kg body weight, larger doses can only cause vomiting, indicating that this compound is very toxic.
"500mg per kilogram, my weight is"
After weighing himself, Mark found that the extra injection dose he received was 30,000 mg. To be on the safe side, he increased the dose. When the bright red dye was sucked into the syringe, Mark tied his arm with a tape, then inserted the needle into the vein and slowly injected it. As he watched the bright red dye being injected into his body, he felt extremely nervous. Suffocation, which is a last resort, can this compound kill bacteria in one's own body?
"Teacher, you"
Just after he injected the last compound, his student Wei Fangping walked in.
"Fang Ping, you take the record, inject compound: 4-
Sulfonamide
¨C
2,4-
Diamine azobenzene hydrochloride, injection test body weight 55 kg, injection dose: 50000mg"
Facing the students, Marko, who was holding back the feeling of vomiting, began to talk about the test data and his feelings after injecting the drug. At this time, he completely forgot that he was saving his own life, and instead devoted himself wholeheartedly to this experiment. Regardless of whether it was successful or not, he could at least obtain first-hand human experiment data.
As time passed, Wei Fangping took the teacher's temperature every half hour. In the first three hours, his body temperature did not show any downward trend. At this time, Marko even had some consciousness due to the high fever. Fuzzy, but he still kept spitting out his feelings.
¡°Test subject three hours after injection¡¡±
While talking, after taking a sip of tea, Marko could feel that his mind seemed to be more comfortable than before, and no longer as dull as before.
And the body temperature seems to have dropped a bit, which should be an indication that his body is developing for the better.
"How about it?"
Through the glass window, looking at Marko lying on the bed, Xiang Songmao rubbed his hands nervously. Professor Ma was experimenting on himself. Although he was saving his own life, he couldn't help but worry about him.
"The body temperature has dropped, but the specific effect is not yet clear. I hope it will be effective!"
Time passed by, and slowly there were more and more people in the corridor. Almost everyone in the institute knew that the director of the institute, Professor Mark Duo, was conducting experiments with his own body, and the process of the experiment was really shocking. People are worried. In the past few hours, Professor Makto has been vomiting.
"Five hours after the test, the second injection was performed, and the injection dose was doubled!"
A few minutes later, at Marko's strong request, his student and assistant Wei Fangping began to give him an intravenous injection. At this time, his appetite had gradually recovered, and he stared blankly at the honey in his palm. cake. Although he had no appetite, he still reluctantly brought the cake to his mouth. Suddenly, he felt nauseated and uncomfortable.
"Ugh"
Covering his mouth about vomiting, Mark rushed to the toilet in the ward and vomited in the washbasin. The vomit was all gastric juice, and he finally finished vomiting. He rinsed his mouth with water, turned on the light in the bathroom, and opened his eyes wide in surprise, looking at himself in the mirror. Why is your face so red?
At first, he thought it was an illusion, but when he looked closer, his face was indeed red, which was obviously caused by the dye injected into the body.
"I didn't expect that I would become a celebrity now?"
Panting, Marko spoke intermittently, but unlike before, he already felt much lighter all over. At least he no longer felt as heavy as he did a few days ago.
Lying on the bed again, Mark closed his eyesHe raised his eyes and thought over every sentence in the test report. Although he still couldn't figure out the mechanism of action of this compound on bacteria and what substances in it could kill bacteria, he felt that the drug was taking action in his body. It has successfully prevented the further spread of bacteria.
Thinking of this, his heart was beating wildly like a big bell, and suddenly he was no longer as afraid of death as before, but full of confidence in this drug.
"If it gets better, we must study this drug carefully."
Although it is only a trial, Marko knows that if this trial is successful, this drug may change the entire world. By then, millions of people around the world may be saved because of this drug, especially in today's world. During the war, during the "Jiao'ao Incident", thousands of soldiers died from bacterial infections in their wounds. If this drug could save him, it could save others.
Looking at Marko in the room through the window, Xiang Songmao looked at him intently. He could see his fluffy hair and a thoughtful look under his broad forehead, even though his face was abnormally bright red. But now anyone can notice that Professor Ma's body is getting better, which means that the medicine has taken effect.
¡°If successful, this drug could change the world!¡±
"Pneumonia can even be cured by then!"
"If it had been a few months earlier, there wouldn't have been so many wounded soldiers dying in the hospital!"
"It's just that the color is a bit too ugly!"
"Compared with life, turning red is no big deal, not to mention, you can recover slowly!"
Listening to the conversation of those people, Xiang Songmao, who looked at Mark Duo, became a little excited. Although he was a layman in medicine, he knew what this medicine meant, it meant wealth, it meant, Well, it means a political weapon. This kind of medicine can save the lives of countless soldiers on the battlefield. While this kind of medicine brings huge profits to the company, the country can also use it as a weapon to export medicines in exchange for some Unexpected benefits.
As a businessman, Xiang Songmao knows how to maximize the power of the "weapons" in his hands. His weapons are medicines. Now, if Mark is successful, then he will undoubtedly have an unprecedented "weapon" in his hands. Super Weapon".
¡°Two hours after the second injection of 25,000mg, the physical condition of the test recipient improved significantly, and his consciousness was basically awake. Well, the body temperature dropped to normal"
Pushing himself up, Marko had a smile on his face. At this time, he was able to write the test report with his own hands.
"Teacher, the blood culture results are out."
At this time, Wei Fangping came over with another report.
"Teacher, the bacteria in your body have been reduced by more than 90% compared to the first injection. You will fully recover soon!"
When handing the report to the teacher, Wei Fangping looked at his tutor and said seriously.
"Teacher, this experiment of yours will change the whole world!"
Then, he said with emotion.
¡°For the first time, we Chinese have created a drug in modern medicine that can change the history of the world!¡±
It¡¯s enough to change world history!
At this time, Marko's face, which was dyed bright red by the drug, flashed a smile from the bottom of his heart. He knew that he had succeeded. It shouldn't be half the battle. If he wanted this drug to be truly successful, there were still many things to do. There is work to be done.
"Fangping, we still have a lot of things to do, this is just the beginning!"
At the same time, he cast his gaze out of the glass window and looked at the company manager through the window. At this time, Xiang Songmao took the initiative to open the door and walked in. He looked at Marko, who had basically recovered, and said.
"Okay, Professor Ma, it goes without saying that I know that the test should have been successful, but"
Staring at those strangely red faces, Xiang Songmao continued.
"Now, the most important thing for you is to rest. Research on new drugs is not in a rush for a few days! You must have a good rest these days!"
When leaving the institute, Xiang Songmao's face was full of smiles. This was the first time that the institute did not rely on the company's technical support to successfully research "new Western medicines." When the institute was first established, the company sent With three truckloads of technical data, the Medical Research Institute has been using those data to develop medicines and medical devices in the past year.
The new surgical instruments now exported by the company in large quantities were developed using those data. The European war's demand for surgical instruments reached its peak. Now the instruments areThe export of weapons even exceeds the export of medicines, but if this medicine is successful, it will definitely become the company's flagship product. Five out of every ten wounded on the battlefield are threatened by bacterial infection. In the past, they could only resign themselves to their fate, but now All this is about to change.
What's more important is that this drug was developed by Big Pharma itself. Out of respect for patents, and perhaps to cultivate patent awareness, the parent company charges a fee for each drug when it provides technology to Big Pharma. 30% patent fee, the device also charges 15% patent fee, but this drug was developed by the company's technical staff. Although the patent fee still needs to be paid, it is lower than the patent fee collected by the company, which means He can direct more money toward the growth of Big Pharma.
"Manager! Manager Xiang!"
At this moment, a person ran over. It was Song Qimao, an employee of the company. At this time, his face was full of anxiety, and it was obvious that something had happened.
"Mr. Xiang something big happened!"
Song Qimao, who was still panting, ran to the manager. Tears welled up before he even finished speaking.
A big deal?
Looking at Song Qimao's appearance, Xiang Songmao's heart skipped a beat. What big event could he be referring to? This is obviously not Song Qimao's own business.
"Why are you crying! What's going on? Tell me!"
"Jing, manager, Jing, manager"
A brief envoy? A sense of ominousness emerged from his heart. To the outside world, the manager was just the manager, but to Xiang Songmao and every employee of ** Company's subsidiaries, the manager had another identity, ** Company The chairman of the board of directors, he is their boss, and for Xiang Songmao, the manager is a person who has the kindness to appoint him.
"Jing Lue Envoy? How about Jing Lue Envoy!"
Xiang Songmao shouted loudly as his eyes widened.
"Manager, the manager told him that he was assassinated by an assassin in Shanghai, and now he doesn't know whether he is alive or dead"
What¡¡
Song Qimao's words only made Xiang Songmao feel a tremor of heaven and earth. When he was frightened and angry, a feeling like the sky was falling suddenly enveloped his consciousness.
China is finished!
After coming back to his senses, Xiang Songmao murmured to his lips. When he was panicking and filled with anger, he just shouted.
"Yuan Shikai, damn Yuan Shikai!"
After scolding him, Xiang Songmao looked at Song Qimao and said.
¡°What other news is there now?¡±
Song Qimao shook his head, while Xiang Songmao said a little lost.
"Prepare medicines, there's probably going to be a war!" - Didn't finish reading? Add this book to your favoritesI'm a member and bookmarked this chapterCopy the address of this book and recommend it to your friends for pointsChapter error? Click here to report
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