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Text Episode 15: Farewell to the March 8th Women

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    Viral hepatitis B is a worldwide disease caused by hepatitis B virus (HBV).  /q§£5.  c0m/Developing countries have a high incidence rate. According to statistics, there are more than 280 million asymptomatic hepatitis B virus carriers (hbsag carriers) in the world, and my country accounts for about 130 million.  Most are asymptomatic, and 1/3 of them show clinical manifestations of liver damage.  There are currently 30 million hepatitis B patients in my country.  Hepatitis B is characterized by a slow onset, with subclinical and chronic forms being more common.  Those with persistently positive HBsAG without jaundice are prone to chronicity.  The disease is mainly transmitted through blood, mother-to-child and sexual contact.  The application of hepatitis B vaccine is the fundamental measure to prevent and control hepatitis B.

    Hepatitis B virus is an infectious disease caused by hepatitis B virus (HBV), which mainly causes inflammatory lesions of the liver and can cause damage to multiple organs.  This disease is widely prevalent in countries around the world, mainly affecting children and young adults. A small number of patients can transform into cirrhosis or liver cancer.  Therefore, it has become a global disease that seriously threatens human health. It is also the most widespread and harmful infectious disease in my country.  Hepatitis B virus has no specific epidemic period and can occur throughout the year, but it is mostly sporadic.  In recent years, the incidence rate of hepatitis B has been significantly increasing.

    The pathogenesis of hepatitis B is very complex and there is a lot of research data, but it has not been fully elucidated so far.  It is currently believed that liver cell damage is not the result of HBV replication in liver cells, but is caused by T cell toxicity.  After people are infected with HBV, it can cause cellular immunity and humoral immune responses, and stimulate autoimmune responses and immune regulatory dysfunction.  These immune responses are of great significance to the clinical manifestations and outcomes of hepatitis B.

    1. Acute hepatitis When a person with normal immune function is infected with HBV, its cytotoxic T cells (TC cells) attack the infected liver cells, and the HBV released into the blood by the damaged liver cells is bound by specific antibodies and interferon  More will be produced, causing HBV to be eliminated, and the condition will improve and eventually be cured.

    2. Chronic active hepatitis is seen in people with defective immune function and disordered immune regulation.  After infection with HBV, some liver cells are damaged due to abnormal Tc cell function or specific antibodies blocking some hepatocyte target antigens and restricting the T cell toxic response.  Interferons are produced less and HBV continues to replicate.  Insufficient formation of specific antibodies leads to repeated invasion of liver cells by HBV, resulting in chronic infection.  In addition, liver cell membrane-specific lipoproteins (LSP) form autoantigens due to HBV infection, stimulating B cells to produce anti-LSP (Igg type). When the activity of inhibitory T cells (TS cells) is reduced, the autoimmune ADCC effect causes  Progressive damage to liver cells.

    3. Chronic persistent hepatitis and asymptomatic HBsag carriers, when infected with HBV when their immune function is low, cannot produce an effective immune response, resulting in slight or no liver cell damage.  Especially asymptomatic hbeag carriers lack interferon and cannot clear the virus, resulting in long-term carriers of hbv.  4. Severe hepatitis The occurrence of acute severe hepatitis is due to the body's excessive immune response. The T cell toxic reaction rapidly destroys a large number of HBV-infected liver cells in a short period of time; or a large number of antigen-antibody complexes are formed in a short period of time to activate complement and cause local hypersensitivity.  reaction (arthus reaction), causing necrosis of large pieces of liver cells; absorption of intestinal endotoxin can cause schan reaction, causing ischemic necrosis of liver cells; addition of a-tumor necrosis factor (tnf-a), il-1  Cytokines such as and leukotrienes are released by monocytes and macrophages and promote liver cell damage.

    The pathogenesis of subacute severe hepatitis is similar to that of acute severe hepatitis, but its progression is slower.  The pathogenesis of chronic severe hepatitis is complex and needs further study.  Hepatitis B virus carriers are not contagious.

    The incidence of hepatitis B is familial or sporadic. People who are congenital or infected at birth usually carry the virus chronically or even for life. People infected later in life rarely develop chronic hepatitis B.  From this perspective, the infectivity of hepatitis B mainly affects family members, blood, blood products, surgery, trauma, etc.  General exposure will rarely lead to HBV infection and cause chronic hepatitis B.  The vast majority of normal people, after being exposed to HBV, have normal immune response and processing systems in their bodies. When the virus invades the body, it can be detected and eliminated in time. This process is carried out by most people unconsciously.  proceed and complete.  If the following situations occur, it may mean that HBV is in a highly infectious period.

    Complications: Hepatogenic diabetes, clinical manifestations are similar to type 2 diabetes. The difference is that in hepatogenic diabetes, insulin is significantly increased during fasting but c-peptide is normal.  After taking sugar, the insulin level increased significantly but the peak value of C was still slightly lower than normal.  This is because the liver's ability to inactivate insulin is reduced, causing insulin to rise; in addition, glucagon is less inactivated in the liver, and insulin receptors on liver cells are reduced, resulting in resistance to insulin. Therefore, although insulin rises, blood sugar remains high;  At the same time, c-peptide is less affected by the liver, so c-peptide is not high, indicating that there is no obvious abnormality in the secretory function of ¦Â cells.  To identify type 2 diabetes, insulin release test and c-peptide release test can be used.

    Fatty liver: The mechanism is still unclear, but it is characterized by good general condition, mild or moderate elevation of single alt, increased blood lipids, fatty liver waveform visible on b-mode ultrasound, and diagnosis based on pathological examination of liver biopsy.Cirrhosis: Chronic hepatitis develops into cirrhosis, which is the result of liver fibrosis.  The mechanism of occurrence has not been fully elucidated.  It is still seen in subacute, chronic severe hepatitis and asymptomatic hbsag carriers with insidious onset.

    Liver cancer: HBV and HCV infection are closely related to its onset.  Liver cancer is more common in patients with chronic liver disease and cirrhosis.  It can also be seen in chronic HBV infection that develops into liver cancer without the cirrhosis stage.  Its mechanism is currently believed to be related to HBV-DNA integration, especially X gene integration.  hbxag plays an important role in transactivating proto-oncogenes.  In addition, carcinogens such as aflatoxin have certain synergistic effects.

    Hepatic encephalopathy: Hepatic encephalopathy, also known as hepatic coma, or hepatocerebral syndrome, is a common complication of end-stage liver cancer.  It is characterized by dysfunction of the central nervous system and metabolic disorders, with mental retardation, disturbance of consciousness, neurological signs and liver damage as the main clinical manifestations. It is also one of the common causes of death from liver cancer, leading to the death of about 30% of patients.

    When the hepatitis B virus invades the human body, about 65% of the infected people do not become ill, and only show short-term subclinical symptoms, including mild and transient fatigue and anorexia. Most of the infected people do not mind, and  The hepatitis virus in the body has been cleared, high levels of surface antibodies have been produced, and longer-lasting immunity to hepatitis B has been obtained.  About 25% of infected people will develop the disease, showing a typical clinical course of acute jaundice or acute anicterus.  About 10% of infected people often change from acute to chronic or present with chronic hepatitis B from the beginning.

    Liver disease experts said that hepatitis B is a contagious disease and is also highly contagious.  As for the question of whether hepatitis B is serious, it needs to be judged based on the comprehensive examination results of liver function test, hepatitis B virus DNA test and B-ultrasound examination.  If the liver function of a patient with hepatitis B is abnormal, hepatitis B virus DNA is positive, and B-ultrasound examination shows mild fibrosis in the liver, then the condition is relatively serious and requires immediate treatment to control further deterioration of the condition.  If the liver function is normal and the hepatitis B virus DNA test is negative, it means that the condition is not serious and no treatment is needed temporarily. Liver function only needs to be checked regularly.

    Ishii Twenty-san actually didn't know that he was infected with the hepatitis B virus. For him, the weakness would last for at least a week. There are only a few reasons for the vampire's weakness, such as sunlight, werewolf saliva, and blood.  Diseases such as Solar Scourge are mainly caused by the chemical reaction of ultraviolet rays in sunlight on vampires, which eventually causes the vampires to become weak and die. The werewolf's saliva reacts chemically with the structure of the vampire's body, eventually causing the blood to coagulate, which is difficult to solve.  .  Finally, there are blood diseases.

    Including diabetes, AIDS, cancer, and various infectious liver and kidney diseases, these are poisons to vampires. Fortunately, vampires have powerful self-healing capabilities, so they can only cause weakness for a period of time.  But basically there is still a chance to recover gradually. If it weren't for the vampire's powerful self-healing ability, it would be basically hopeless if he encountered a blood disease.

    If the current Ishii Twenty-san had not provided plasma from Foxconn, it would have been difficult for him to withstand the extreme weakness during this period. However, fortunately, Ishii Twenty-san is still relatively tenacious. After learning about Sun Xingchen and  After Chen Congcong was wanted, he switched driving shifts with Cheng and his son, and planned to drive straight from Guangdong to Harbin.

    Normally, if you take the expressway from Guangdong to Harbin, it will take at least about seven days, but fortunately, Ishii Twenty-san has now found an organization, and it can even be said that there is no shortage of money.  There was an identity and a car ready nearby, specifically for Ishii Twenty-san to change the car. Just like that, while Chen Congcong kept avoiding it, Ishii Twenty-san drove straight to Harbin. This was no longer possible with a thousand-mile attack.  To describe it, it¡¯s like traveling thousands of miles away!

    At the beginning, Secretary Cheng and Mr. Cheng wanted to take the opportunity to escape, but since they saw Ishii Twenty-san wearing sunscreen, wearing polarized sunglasses with UV protection, sitting happily in the back and drinking plasma from the bag,  Secretary Cheng and Young Master Cheng Mingyuan were so deep in silence that they just thought about this monster coming and going like the wind. If they were discovered when they were escaping, it would be a direct disaster

    In fact, Secretary Cheng is quite cunning. When he was first captured by Ishii Twenty-san, he claimed that he was diabetic, and his son Cheng Mingyuan, Cheng Mingyuan, was a hepatitis B carrier. Ishii Twenty-san did not dare to commit suicide easily.  Mouth, after all, China's population is still too large. With such a large population on a limited land, it is inevitable that they will be infected with various diseases, so Ishii Twenty-san is more cautious here.

    Just like this, I kept driving on the highway in silence. During this period, I had changed three or four cars. Now I was driving a Guangzhou Honda with a Shandong license plate. I was approaching Shenyang early in the morning of the fourth day.  ??You can even see downtown Shenyang right away from the expressway. As long as you keep driving along the expressway, you can reach Harbin in six to eight hours. But after all, it is still the twelfth month of winter, and the weather is cold and the roads are slippery.  Mr. Bian Cheng was a little frightened when he became famous.

    It¡¯s not without reason for Mr. Cheng to be frightened. Since Ishii Twenty-san came all the way from Guangzhou, he was required to drive at a speed of not less than 100. Moreover, the Chinese New Year is coming soon, because he can¡¯t buy train tickets or air tickets.  Many people choose to drive home, which is more expensive than flying, just to reunite with their families. This is also an interpretation of the Chinese people's concept of family.

    Facing the traffic jam, he still has to maintain a speed of more than 100 kilometers per hour. Although Cheng Gongzi Chengmingyuan loves racing and is also a member of the speeding party, if he wants to maintain this speed for a long time, he has to do it at any time.  It was a bit too difficult to keep from being rear-ended or being rear-ended, even maintaining this speed on icy and snowy roads, so Mr. Cheng decided to muster up the courage to discuss it with Ishii Twenty-san, although Ishii Twenty-san usually only issued orders  Except for orders, he basically remained silent in the car, so it was easy to cause driving fatigue along the way.

    The driving fatigue of Secretary Cheng and Mr. Cheng is not only caused by this, but also by the fact that Ishii Twenty-san is a blood-sucking monster after all. Facing such a monster, after all, it is a bit confusing, so  Mr. Cheng hesitated for a while before he said coyly to Ishii Twenty-san: "Fellow fellow! I really can't stand it anymore. You see, we are going to Shenyang soon. How about me and my dad getting off the bus in Shenyang?"  I promise not to report the case, and I promise not to talk about you!¡± (Secretary Cheng and his son are from Shandong, and Shijing Twenty-san also has a Shandong accent, so they misunderstood that Shijing Twenty-san was a fellow Shandong fellow, as explained in the previous article.)

    Ishii Twenty-san pondered for a while, but still had no intention of agreeing. After all, having Secretary Cheng and Mr. Cheng in his car now would be a cover for him. After all, if he was wanted, it would be through Cheng and his son.  To attract his own attention, after all, he is the only one who is wanted, and Cheng and his son are two people after all. If they attract the attention of the Chinese court through them, he will just blend in with the crowd.

    In the past few days, Ishii Twenty-san used the BlackBerry brought back by Cheng Mingyuan from Iceland to read the news online. Sun Xingchen has been arrested, and now only Chen Congcong is on the run. If he returns to Harbin at this time, either  With the last intelligence organization sent by the Japanese side, Chen Congcong was rescued, or he was left in Harbin.

    Just as Ishii Twenty-san fell into silence, Cheng Gongzi Cheng Mingyuan continued to chirp silently: "Fellow fellow! Look, we have just returned from an inspection tour in Europe and are planning to show off our talents in Liaoning.  And we can¡¯t help you by following you, and we¡¯re not good at eating, and we¡¯re sick"

    The pensive Ishii Twenty-san was very frustrated by Mr. Cheng's fame, and said angrily: "You 38-year-old woman, please shut up your stinky mouth for me, or I will kill you two now."  , we must get to Harbin within six hours, and I will let you go when we get to Harbin, otherwise I will kill you two now and then drive back to Harbin by myself!"

    Ishii Twenty-san's "March 8 women" shocked Chenggongzi Chengmingyuan so much that Chenggongzi Chengmingyuan immediately shut up, then increased the accelerator, and drove hard all the way to Harbin, for no other reason than  For what Ishii Twenty-san said just now, give yourself freedom and let yourself and your father return to Shenyang. How can you deceive yourself for someone as capable as Ishii Twenty-san?

    Mr. Cheng's scheming can't be compared with his father, Secretary Cheng. Secretary Cheng has long seen that Ishii Twenty-san is planning to use his father and son. It is estimated that after the use is over, the only way is to silence them.  , after all, I saw Ishii Twenty-san being cruel and ruthless not just once along the way. When we met for the first time, I saw that almost all the muscles in his lower body legs were torn, and his pants were not complete. If it was true  If you follow this murderous god, you will definitely be in trouble, but your stupid son is so stupid that you really believe him!

    The frowning Secretary Cheng did not say a word. After all, if he pierced this layer of window paper now, he would have to face the direct silence of Ishii Twenty-san. If he could survive for a while longer, he would be able to ensure more  A chance to escape, but if we really reach the urban area of ??Harbin, how can we save our lives?

    Now there is only one way to save your life when you return to Harbin, which is to surrender directly. While you are still wanted, after surrendering, you can directly get rid of Ishii Twenty-san, and if Ishii Twenty-san resists  If it is a state machine, then it must be a tragic result!  But in this way, I have suffered so much in vain, first plastic surgery, and thenI ran to Iceland, and then foolishly made a plan to return to China. The final outcome was that all my efforts were in vain. This result is really hard to accept, and it makes people feel that it came out of the blue.  Heart-wrenching pain in the balls.

    Looking at the unclear road ahead, the only thing Secretary Cheng can do now is to try his best to delay time. How to protect himself and his son under the intimidation of Ishii Twenty-san, how to survive is the top priority. The rest  Everything was just a cloud, and now I am using my brain like Brother Ikkyu

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    Ishii Twenty-san sneered and smiled at Secretary Cheng: "In front of you, a pair of March 8th women who read books and don't know how to spend red tickets or pay party dues, all the conspiracy and conspiracy are just a cloud"

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